Center for
Molecular Intelligence

Intelligence of Human X Machine at Molecular Quantum Level for Medicines and Materials.

Center for
Molecular Intelligence

Intelligence of Human X Machine at Molecular Quantum Level for Medicines and Materials.

From the Director

At CMI, located at the Incheon Global Campus of the State University of New York, we are passionate about unraveling the intricate mysteries of life at the molecular and quantum level. Our dedicated research center is committed to exploring the fundamental basis of life through highly interdisciplinary approaches.

We tackle three primary challenges that drive our scientific endeavors. Firstly, we strive to overcome the experimental challenges associated with studying life phenomena at the molecular and atomic level, where quantum principles dominate. By pushing the boundaries of knowledge, we aim to unlock new insights into the workings of life itself.

Secondly, we aim to bridge the microscopic world of trillions of cells with real-world bodily phenomena. Our mission is to establish a comprehensive biology model that seamlessly integrates these realms, providing a deeper understanding of the complex processes that govern life's functions.

Lastly, we are driven by the pursuit of developing medicines that can achieve efficacy without harmful side effects. Through innovative research and cutting-edge technologies, we strive to contribute to the advancement of medical science and improve the well-being of individuals worldwide.

We invite you to explore our website and discover the groundbreaking research, visionary scientists, and transformative discoveries that define CMI. Join us on this exciting journey as we uncover the molecular intelligence that underlies life itself.

Welcome to CMI, where scientific curiosity meets molecular enlightenment.


Howard Shin, Ph.D.

Center for Molecular Intelligence, SUNY Korea

Latest Research

Marine Drugs, 2022

Regioselective Synthesis of 6-O-Acetyl Dieckol and Its Selective Cytotoxicity against Non-Small-Cell Lung Cancer Cells.

J. Am. Chem. Soc. 2023

Conformationally Restricted Glycopeptide Backbone Inhibits Gas-Phase H/D Scrambling between Glycan and Peptide Moieties.


The year of


10+ countries of
international collaborations


50+ institutions
of collaboration


80+ Scientists of
Our History

SUNY Korea was established in March 2012 as the first American university system in Incheon, South Korea. In 2012, Stony Brook University which is a prestigious university that represents the SUNY system began to offer programs in South Korea as part of the Ministry of Education’s decision to serve the transnational needs for quality and global education.

Our center was first established as “CEWIT Center for Systems Biology” at SUNY Korea in 2012 focusing on the systems approach in developing therapeutics for chronic degenerative diseases.

In 2017, it was re-established as “Center for Molecular Intelligence” focusing on bridging the gap between macroscopic biology and molecular quantum physics by using computational and digital approach based on S.Q.U.I.D. molecular system.

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Our People

S.Q.U.I.D. Molecular System

One of our approaches to tackling these challenges has been inspired by the molecular system found in certain brown algae, known as "Marine Polyphenols." This remarkable system is based on a single monomer called "Phloroglucinol," which can generate an unlimited variety of molecular structures depending on the number and arrangement of monomers involved.

What sets this molecular system apart is its unique combination of medicinal potentials, not found in other molecular systems. We have recently coined the term "S.Q.U.I.D." to represent this exceptional combination.

  • Safe: These molecules are non-toxic and free from side effects.
  • Quantum pharmacological: They can interact with cells at the quantum level, enabling more effective and precisely targeted treatments.
  • Ubiquitous: These molecules have the ability to access a wide range of cellular, subcellular, and systemic spaces.
  • Intelligent: They can adapt to the biological context, enhancing their effectiveness without compromising safety.
  • Digital: These molecules can be manipulated using digital technology, forming a platform for small-molecule pharmaceuticals.

We firmly believe that the S.Q.U.I.D. molecular system holds immense potential to revolutionize the field of therapeutics. By comprehending the molecular basis of life in conjunction with this innovative molecular platform, we can develop new drugs and therapies that are not only more effective but also safer and more affordable.

At CMI, we are driven by the vision of transforming the way diseases are treated. Join us on this groundbreaking journey as we explore the possibilities unlocked by the S.Q.U.I.D. molecular system.


Kwon YJ, Kwon OI, Hwang HJ, Shin HC, Yang S, Therapeutic effects of phlorotannins in the treatment of neurodegenerative disorders. Front. Mol. Neurosci., 2023, Volume 16.

Shin HC, Kim Y, Choi J, Kang HB, Han SY, Park K,  Hwang HJ, Regioselective Synthesis of 6-O-Acetyl Dieckol and Its Selective Cytotoxicity against Non-Small-Cell Lung Cancer Cells. Mar. Drugs 2022, 20(11), 683.

Li H, Oh SH, Shin HC, Suh MW. Intratympanic Administration of Dieckol Prevents Ototoxic Hearing Loss. Mar Drugs 2022, 20(10), 622.

Shin HC, Wayas IB, Choi BW, Lee BH, Identification and Biological Activities of the Phenolic Compounds in Eisenia arborea. Am J Plant Sci. 2021, 12, 259-265.

Kim Y, Shin J, Shin HC, Park K, Regioselective syntheses and analyses of phlorofucofuroeckol-A derivatives. Bull. Korean Chem. Soc. 2021, 42, 1624-1632.

Kwon IS, Park DS, Shin HC, Seok MG, Oh JK. Effects of marine oligomeric polyphenols on body composition and physical ability of elderly individuals with sarcopenia: a pilot study. Phys Act Nutr. 2021, 25(3), 1-7.

Woo H, Kim MK, Park S, Han SH, Shin HC, Kim BG, Oh SH, Suh MW, Lee JH, Park MK. Effect of Phlorofucofuroeckol A and Dieckol Extracted from Ecklonia cava on Noise-induced Hearing Loss in a Mouse Model. Mar Drugs 2021, 19(8), 443.

Lee JG, Hwang HJ, Lee YS, Shin HC. Conformational Isomerism for Eckol and its Skeleton: Theoretical Study. Bull. Korean Chem. Soc. 2019, 40, 935-936.

Zhang D, Wang Y, Sun X, Zhou Y, Shin HC, Wang Y, Shen L, Wang C, Wang S, Zou X. Voltammetric, spectroscopic, and cellular characterization of redox functionality of eckol and phlorofucofuroeckol‐A- A comparative study, J. Food Biochem. 2019, e12845.

Zhang D, Wang C, Shen L, Shin HC, Lee KB, Ji B. Comparative analysis of oxidative mechanisms of phloroglucinol and dieckol by electrochemical, spectroscopic, cellular and computational methods. RSC Advance 2018, 4, 1963.

Ahn HS, Lee DH, Kim TJ, Shin HC, Jeon HK. Cardioprotective Effects of a Phlorotannin Extract Against Doxorubicin-Induced Cardiotoxicity in a Rat Model. J Med. Food 2017, 20(10), 944-950.

BT Nixon, K Mansouri, A Singh, J Du, JK Davis, JG Lee… Comparative structural and computational analysis supports eighteen cellulose synthases in the plant cellulose synthesis complex. Scientific reports, 2016, 6:28696.

…, NH Voelcker, HDT Mertens, NM Kirby, JG Lee… A barley efflux transporter operates in a Na+-dependent manner, as revealed by a multidisciplinary platform. The Plant Cell, 2016, 28(1): 202–218.

Chang MY, Han SY, Shin HC, Byun JY, Rah YC, Park MK. Protective effect of a purified polyphenolic extract from Ecklonia cava against noise-induced hearing loss: Prevention of temporary threshold shift. Int. J. Pediatr Otorhinolaryngol. 2016, 87, 178-184.

Chang MY, Byon HS, Shin HC, Han SY, Kim JY, Byun JY, Lee JD, Park MK. Protective effects of the seaweed phlorotannin polyphenolic compound dieckol on gentamicin-induced damage in auditory hair cells. Int. J. Pediatr Otorhinolaryngol. 2016, 83, 31-36.

Kwak JH, Yang Z, Yoon B, He Y, Uhm S, Shin HC, Lee BH, Yoo YC, Lee KB, Han SY, Kim JS, Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors. Biomaterials 2015, 61, 52-60. (2015) 

Choi BW, Lee HS, Shin HC, Lee BH, Multifunctional Activity of Polyphenolic Compounds Associated with a Poential for Alzheimer’s Disease Therapy from Ecklonia cava. Phyother Res. 2015, 29(4), 549-553.